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Because of limited experience in children and no data in HIV-infected children, data are insufficient to recommend these drugs as first-line agents for invasive candidiasis in children ( CIII).

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An isopropylalaninyl monoamidate phenyl monoester prodrug of tenofovir (GS 7340) was prepared, and its in vitro antiviral activity, metabolism, and pharmacokinetics in dogs were determined.

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Additionally, frequent intravitreous injections are impractical for use in most children ( DIII).

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The prozone phenomenon (a weakly reactive or falsely negative) reaction might occur more frequently in HIV-infected persons ( 147).

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Tenofovir DF in highly antiretroviral-experienced patients: results from a 48-week, randomized, double-blind study.

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This review summarizes TDF safety during pregnancy, focusing on pregnancy outcomes, congenital anomaly risk, and other potential toxicities on neonates.

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Trimethoprim--sulfamethoxazole (TMP-SMZ) dose escalation versus direct rechallenge for Pneumocystis carinii pneumonia prophylaxis in human immunodeficiency virus-infected patients with previous adverse reaction to TMP-SMZ.

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The current document combines recommendations for preventing and treating OIs in HIV-exposed and HIV-infected children into one document; it accompanies a similar document on preventing and treating OIs among HIV-infected adults prepared by a separate group of adult HIV and infectious disease specialists.

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These results are consistent with the data generated in MT-2 extract and isolated plasma; however, unlike the MT-2 extract, conversion to the active diphosphate metabolite was readily observed with intact MT-2 cells and PBMCs.

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