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Instruct patient to drink 3 liters of fluid on the day of treatment and the following day.

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Cyclophosphamide (sye" kloe fos' fa mide) is a synthetic, nitrogen mustard-like alkylating agent that is widely used in the therapy of cancer and in severe forms of autoimmune disease.

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Small cohort studies have indicated that rituximab could have an important role in the management of these disorders.

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Taking proper precautions and care of the skin can be beneficial for symptoms of Raynaud's phenomenon and for the dry, thick patches of skin that result from localized scleroderma.

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Although adverse neurocognitive outcomes observed 5 to 10 years after treatment are presumed to be pervasive, and potentially worsen over time, few empirical data are available regarding the neurocognitive functioning in very long-term survivors of CNS tumors.

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