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When an alkyl residue having a specific number of carbons is named, all geometric isomers having that number of carbons are intended to be encompassed; thus, for example, “butyl” is meant to include n-butyl, sec-butyl, isobutyl and t-butyl; “propyl” includes n-propyl and isopropyl.
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Use of biomarkers to select the target population for clinical trials in subjects with mild cognitive impairment.
Parkinson's disease (), ameliorate chronic pain (), and improve recovery from traumatic brain injury ().
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In some embodiments, a therapeutically effective amount of a chemical entity is an amount sufficient to increase the anticonvulsant and neuroprotective properties associated with lowered levels of QUIN and increased levels of KYNA.
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