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If you become pregnant while taking imatinib, talk to your doctor right away about the risks and benefits of this medication.

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For patients with GISTs that have a high risk of recurrence (coming back) after surgery, doctors now recommend that they take imatinib (Gleevec) for up to three years as a preventive measure.

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Our results demonstrating Gleevec's high efficacy in CML tell us that in applying the drug to other cancers, we need to diagnose and treat patients earlier in the disease course.

Avoid combinations; the risk of the interaction outweighs the benefit.

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Serious side effects with GLEEVEC include severe fluid retention (holding water), which can cause swelling around the eyes or swelling of the lower legs, lungs, and heart, which can be fatal in rare cases; increased pressure in the heart or brain, also fatal in rare cases; low levels of certain blood cells, heart failure, liver problems, hemorrhage (abnormal bleeding), skin blistering, and low levels of thyroid hormone.

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With standard therapy, patients with lymphoid blast crisis have higher rates and greater durability of response than those with myeloid blast crisis.

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The result is that a is created by juxtapositioning the on chromosome 9 (region q34) to a part of the ("breakpoint cluster region") gene on (region q11).

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Yuichi Takayama, Toshio Kokuryo, Yukihiro Yokoyama, Masato Nagino, Yuji Nimura, Takeshi Senga, Michinari Hamaguchi.

If PEITC or PL-induced cellular ROS level is taken as the reference of toxic threshold, the higher ROS concentrations would be more toxic.

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In this review we present the current knowledge on CML treatment with focus on imatinib.

SM tested KIT D816V mutation positive.

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During the first phase, the cancer cells are growing slowly.

You will be evaluated one month prior to trial entry, at the initiation of treatment, every month for one year, and three months after withdrawal of study medication.

Another uncommon but potentially serious side effect involves cardiotoxicity in the form of reduced heart function involving the left ventricle of the heart.

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He said that he is giving Novartis a little more time to reconsider his proposal, but that he will declare it a matter of public interest next week when he returns from a World Health Organisation meeting in Geneva.

Long-term outcomes of HLA-matched sibling compared with mismatched related and unrelated donor hematopoietic stem cell transplantation for chronic phase chronic myelogenous leukemia: a single institution experience in China.

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GEORGE DEMETRI: That cell makes a mutation; makes a mistake in copying the code of life: the DNA.

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The disease usually affects people in their 50s and 60s but may affect a person at any age.

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Inhibitors of CYP3A4 would increase blood levels of Gleevec, thereby effectively increasing the dose and exacerbating side effects.

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She didn't have any severe side effects due to the treatment, though she experienced some skin discoloration and muscle cramping.

Targeted drugs are very helpful in treating GISTs, while standard chemo drugs are usually not effective.

But as soon as the medication is over there are re ocuurences of blebs.

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Studies indicate considerable success with adjuvant treatment but the length of time it will work is unknown.

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Treatment is radiation therapy of the involved testis and administration of systemic reinduction therapy as for isolated CNS relapse.

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The pharmacokinetics were similar in healthy volunteers and in the solid tumor patient populations tested, including patients with GIST and RCC.

The instrument, called an endoscope, is gently inserted through the mouth and lowered into the esophagus, stomach and upper part of the small intestine to look for the source of the bleeding.

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Your doctor may occasionally change your dose to make sure you get the best results.

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Early in these trials, however, the imatinib dose was increased to 600 mg per day for patients with accelerated phase and with blast crisis and patients with resistant or progressive disease could receive doses up to 800 mg per day (administered as 400 mg twice daily).

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